Essential Fatty Acids or SPM (Specialized Pro-Resolving Mediators) are omega-3 derived supplements designed to help modulate and resolve inflammation. Here’s a detailed overview of SPMs, their function, and benefits:
What are SPMs?
- Specialized Pro-Resolving Mediators: Recently discovered substances derived from omega-3 and omega-6 fatty acids.
- Natural Occurrence: Produced in various body parts, including the bloodstream, nervous system tissue, and breastmilk.
Function of SPMs:
- Inflammation Resolution: SPMs do not block the initial inflammatory response but help control the duration and magnitude of inflammation.
- Return to Homeostasis: Promote tissue homeostasis and normal functioning by resolving inflammation.
Inflammation and Its Impact:
- Types of Inflammation: Acute (necessary response to trauma or injury) and chronic (associated with disease conditions).
Mechanism of SPMs:
- Role in Inflammation: SPMs prevent excessive inflammation and facilitate the natural resolution of the inflammatory response.
- Examples of SPMs: Include resolvins, protectins, and maresins, which have potent immuno-regulatory and anti-inflammatory activities.
SPM Production and Supplementation:
- Natural Production: Produced naturally in humans, but production may be compromised in obesity and aging.
- Supplementation Benefits: Supplementing with SPMs may provide relief to individuals struggling with discomfort and prolonged inflammation.
Conclusion:
SPM supplements offer a promising approach to managing inflammation and promoting tissue homeostasis. By supporting the body’s natural ability to resolve inflammation, SPMs can aid in reducing chronic inflammation and associated conditions. This makes them a valuable addition to a health regimen, particularly for those dealing with inflammatory diseases and conditions.